afirma gsc suspicious 50

Without my knowledge 4/5 of my FNA biopsies came out fine but 1/5 had "atypical" cells and they were sent to Afirma without my knowledge. The Afirma test results came back Benign on left side and Suspicious 40% on the right side . This nodule is solid, hypoechoic, increased central vascularity and now possible microcalcification. Bugs me. You cannot become a thyroid cancer specialist in 24 hours needless to say. Euphemia I just read your post about classifications changing. doi: 10.1210/jendso/bvab148. Wow! My surgeon and endocrinologist said no further treatment is needed but to continue observation. I'm ready for my next step. I had a lobectomy sep. 30th. http://biotechstrategyblog.com/2012/06/veracyte- afirma-gene-expression-classifier-thyroid-cancer- diagnostic-test.html/ I'm sure that over the years as more people have this Afirma test done,there will be even more people posting on thyroid and general health boards about getting false "suspicious" results from it! Thyroid cancer is found in ~5% of thyroid nodules, so the vast majority are benign (noncancerous). This occurs in 1520% of biopsies and often results in the need for surgery to remove the nodule. My surgeon wants to operate right away stating that these kind of results have a 90% truancy for cancer to be present. Neither will talk to the other. Mine did, and that can also be a sign of cancer. Good luck and happy thoughts! The results were suspicious of papillary cancer, but not conclusive. Clipboard, Search History, and several other advanced features are temporarily unavailable. Patient medical records were retrospectively reviewed for clinical history, FNA results, radiologic findings, management and follow-up. What do I do? So I gather if I am reading what you reported correctly, your case is another false NEGATIVE for the Afirma test? It just really annoys me that doctors can order tests that cost us money without our consent. The Afirma GSC is a next-generation genomic test that relies on RNA sequencing and advanced machine learning methodology to categorize tissue from cytologically indeterminate FNA biopsy as either benign or suspicious.2 The Afirma gene sequencing classifier (GSC) performs better in indeterminate thyroid nodules than the Afirma gene expression classifier (GEC) BACKGROUND Thyroid nodules are very common, occurring in up to 50% of individuals. There are 3 variants of papillary thyroid cancer: classic, follicular and tall-cell. Genes: a molecular unit of heredity of a living organism. And it keeps growing. the nodule was only 1.5 cm and I really had no concerning symptoms. I have slightly high blood pressure and slightly high cholesterol that are well controlled with meds. I'm also anxiously waiting my pathology results! A month ago I had the Afirma test and it came back positive - suspicious for cancer which increased my chance from 5% to 50%. False Positives. You started down the rabbit hole by focusing on your thyroid gland for no good reason, since the melanoma is not related to anything regarding your asymptomatic thyroid. the GSC is to further differentiate indeterminate FNA. Afirma GSC is a pre-operative genomic test for thyroid tumor biopsies that have . Molecular markers: genes and microRNAs that are expressed in benign or cancerous cells. I was informed in August of 2013 after a FNA that one of my nodules was suspicious and the recommendation was a TT. What should I know? Hello. 5. Noninvasive Follicular Variant of Papillary Thyroid Carcinoma and the Afirma Gene-Expression Classifier. I asked her if I have permission to email and post these articles and she said yes,they are for the public. I didn't want to live with the risk, especially already being hypo and having nodules on the other side slowly growing. Conclusion: My Afirma results also came back as "suspicious." Conversely, when evaluating nodules with suspicious molecular testing, surgical rates were 88% and 89%, respectively, for GEC and GSC (P = 0.853) . The Xpression Atlas reports 905 genomic variants and 235 fusion pairs on GSC Suspicious, Suspicious for Malignancy (SFM), and Malignant FNA samples at the time of diagnosis. There are four types of FVPTV: encapsulated with invasion, encapsulated without invasion, unencapsulated non-invasive and unencapsulated and invasive into the surrounding parenchyma of the gland. Molecular Markers: genes and microRNAs that are expressed in benign or cancerous cells. Her only information about this comes from me, as she lives across the country and can't go to doctor's visits with me. Dincer N, Balci S, Yazgan A, Guney G, Ersoy R, Cakir B, Guler G. Cytopathology. Wong KS, Angell TE, Strickland KC, Alexander EK, Cibas ES, Krane JF, Barletta JA. Indeterminate Thyroid Biopsy: this happens a few atypical cells are seen but not enough to be abnormal (atypia of unknown significance (AUS) or follicular lesion of unknown significance (FLUS)) or when the diagnosis is a follicular or hurthle cell lesion. The Afirma Genomic Sequencing Classifier (GSC) (Veracyte, San Francisco, CA) is a cancer rule-out test that partners whole transcriptome RNA sequencing with machine learning to categorize nodules as benign or suspicious. Mild lymphocytic thyroiditis ( nonspecific) I called my husband before I even received the callback, and couldn't stop crying. 1. for my adopted daughter as she's already lost her bio-parents and thus my husband and I became her new parents.I've stayed like zombie while awaited my total neck ultrasound results and they came back CLEAR any cancer spreading to lymph nodes..yey! 2017 May;125(5):313-322. doi: 10.1002/cncy.21827. Thoughts or experiences?? The result of this 2.1 cm Bethesda IV nodule A is Arma GSC Benign, which suggests a low risk of cancer at approximately 4%. -No Size changes of Nodule in last 2-3 months (duration of time to get all of these tests) They billed my insurance $6684 - my ins negotiatied $3370.40 they have billed me for 883.71, I applied for a reduction but they say I make too much income so I am not eligible for one. 2018 Jul;126(7):471-480. doi: 10.1002/cncy.21993. Wong KS et al. Epub 2018 Apr 10. Genes hold the information to build and maintain an organisms cells and pass genetic traits to offspring. Thank you. Neither will talk to the other. official website and that any information you provide is encrypted Afirma Gene Expression Classifier: a test for a group of molecular markers in thyroid biopsy specimens in order to determine the likelihood that a thyroid nodule is benign or cancerous. Paratracheal nodule (inclduing B1FS): Thyroid Parenchyma, negative for tumor. 2013 Dec;24(6):385-90. doi: 10.1111/cyt.12021. What have been your experinces with AFIRMA? However the "suspicious" result of the Afirma GEC does not classify these indeterminate nodules further in determining appropriate management. Afirma said NEGATIVE for BRAF and Meduliary but still assigned a classification of "Suspicious" with 40% chance of cancer. The current Afirma Genomic Sequencing Classifier (GSC) demonstrates improved specificity, suggesting more nodules will have a benign result (benign call rate [BCR]), but independent data are needed to confirm this in clinical practice. I had my surgery in NYC, it took 2 hours, and I went home the same day. Follicular and hurthle cells are normal cells found in the thyroid. When the nurse called she couldn't even tell me results over he phone -- she said she didn't know them -- but set up an appointment for end of the following week -- another wait. Epub 2020 Mar 17. I was doing some research and came across the Afirma Thyroid Analysis by Veracyte and was wondering if anyone in a similar situation had tried this and what there results were. -5.5cm x 3.9cm x 3.9cm Left Thyroid Nodule: Large mixed/mostly solid, isoechoic, ill-defined margins, macrocalcifications, taller-than-wide: TI-RADS 5 A publication of the American Thyroid Association, Summaries for the Public from recent articles in Clinical Thyroidology, Table of Contents | PDF File for Saving and Printing, THYROID CANCER This process has helped me to realize that there is a lot that physicians do not understand--much more than I knew. I don't know if I'm speaking too soon, but the pain isn't as bad as I thought it would be. The original Afirma Xpression Atlas (XA) panel reported on 761 genomic variants and 130 fusion pairs from 511 genes ( 6 ). My AFIRMA is also 40% risk. I am also concerned about hormone replacement, would like some personnal comments on recovery from Lobectomy versus TT . http://onlinelibrary.wiley.com/doi/10.1002/cncy.21455/full. The surgeon recommended complete removal of my thyroid. 2. However, the interesting twist was that cancer was not detected on the nodules being monitored, there was a little sucker hidden behind all these years according to my surgeon and this was why the pathologist at my local hosp could not come up with definitive conclusion as he/she was only focused on the biopsied nodules:( While most thyroid nodules are non-cancerous (Benign), ~5-10% are cancerous. Afirma BRAF V600E o Afirma BRAF testing may be considered for either GSC or FNA suspicious or malignant results. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). I had that one sent to Afirma, and it came back indeterminate on cytopathology again, benign on GEC. Finally, the cells were sent to Afirma, Now I was growing concerned. The Afirma MTC may not be billed separately using an additional unit or procedure code. But still my labs are all within normal range. The . Advice needed please. I opted for a total after much thought because I had three un biopsied nodules on the other side and was already hypo with my entire thyroid to begin with. Thyroid Fine Needle Aspiration Biopsy (FNAB): Change In Thyroid Nodule Volume Calculator, Find an Endocrinology Thyroid Specialist, Clinical Thyroidology for the Public (CTFP). All I can say is that in reviewing my ultrasounds and the report from the interventional radiologist and the Affirma report, I have noticed that there are inconsistencies in even the reported measurements of the nodules and now that I have read further into studies done on people undergoing thyroid removal after getting "Suspicious"/40% of Cancer Affirma results, there are many more false positives than Afirma would have you understand. Hello, new here and confused, anxious and a bit worried. Cancer Cytopathol. Genes hold the information to build and maintain an organisms cells and pass genetic traits to offspring. After reading many stories, I didn't know what to expect. Here is what the Affirma test disclaimer said: Benign: Preformance characteristics not defined for nodules less than 1 cm diameter. Have lots of decisions to make and just trying to do some homework. Among the 25 papers that approached Afirma GEC, four studies enrolled an additional number of 635 TNs from 596 patients to evaluate the Afirma GSC (16, 17, 57, 70). The aim of this study was to find out how often indeterminate thyroid biopsy specimens which were read as suspicious by the GEC test were ultimately diagnosed as noninvasive follicular variant papillary thyroid cancer after surgery. So now I feel I have no choice to take it out (the nodule also grew .5 cm since the Aug test). Now having dodged a few close bullets, I was like wobble head to my new endo's treatment plan which included 100 mci RAI though after reading my path report that I may be at little higher risk with "variant" than most others. No parathyroid tissue identified. I didn't make a big deal about the cost because I am having surgery and they money I paid was my 20% co-pay and my out of pocket limit is almost met. Others understand my need for more information. Thanks so much! The authors concluded that a GEC suspicious test result may include noninvasive follicular variant papillary thyroid cancer as well as classical papillary thyroid cancer. I'm now 3 days post op and other than some difficulty swallowing and talking loud, I'm feeling great. So I was reading about the new kind of fna biopsy called Afirma, and I guess that my question is, is it worth getting it as a second opinion or should I go through with the surgery because of the results not being undetermined. I had three biopsies on a completely solid 2.0cm nodule, all which came back indeterminate/AUS. BTW, I'm about to turn 50 and I have no thyroid issues other than this. I did not get to go under the knife for my TT til this past March. Yesterday my surgeon told me that FNA Biopsy and Affirma are not reliable and said he would be surprised if the post op pathology shows the same findings. Incidental papillary thyroid carcinoma, .2 cm on Left lobe and Thyroid right lobe: 1.2 cm nodule-Papillary thyroid carcinoma, conventional and follicular variant, histologically infiltrating into adherent skeletal muscle: .2 cm and the right lobe: 1.4 cm, both The overall PPV of an Afirma GSC suspicious nodule was 47%, regardless of variant/fusion status. Is one easier to recover from ? My question is then I guess, is it really that bad afterwards managing levels and the other side effects post TT? THE FULL ARTICLE TITLE The third biopsy was sent for genetic testing which came back as suspicious. Thank God I have good insurance but in the end my medical out of pocket for all of this could cost me up to $4,500. So, if you were going to go down that route then this will save you from having a second biopsy. http://www.thyroidboards.com/showthread.php? In early September, at a well-woman visit, my primary care doctor found a lump in my neck and sent me for a sonogram that found three nodules -- one estimated at 3.5 cm, one at 1.5 cm and the third much smaller. detect variants in greater than 50 genes. Abigail. I just wrote that these are 25% of all thycas, but I have read just recently that the figure might be anywhere between 15-25% because there are varying standards for diagnosing these between different institutions. I'm afraid I feel ok now then all of a sudden will begin feeling horrible. One of the hardest things about all of this is the adjustment. Bookshelf I was told my path report from the local hosp was inconclusive so it had to be sent to Mayo Clinic and after almost three weeks after my surgery, I got the word that it was cancerous. It mentions possible microcalcification, which has never come up before. With each step, I'd expected to hear, "yeah, you are a lumpy person, but no cancer." Can someone give me their take on my fna results? 1. The site is secure. Here are some results/Info: I've enjoyed good health for my whole life. We had a long talk and discussed more conservative options, like a partial thyroidectomy, but no rush. I have also read a recent 2015 report that posits that there are built-in subjectivities to begin with at the Ultrasound/Pathology level yielding "Indeterminate" or "Atypical Cells" to begin with that then sets up a natural path to getting a "Suspicious" result from Afirma. I am very resistant to the thought of having a gland removed that is functioning perfectly fine, if it isn't cancer. While most thyroid nodules are non-cancerous (Benign), ~5% are cancerous. These results do not change the risk of malignancy of the (ROM) of the Afirma GSC suspicious result." The pathology report on the removed nodule said: The rate of malignancy in nodules suspicious for neoplasm (SN) on cytology interpretation was 31.2% (5/16). Please, I am looking for any and all thoughts. SUMMARY OF THE STUDY My Afirma results came back suspicious. I'm determined to eek out the positive in this. ThyCa: Thyroid Cancer Survivors' Association, Inc. I'm a 39 years old male. The GSC correctly identified 41 of 45 malignant samples as suspicious, yielding a sensitivity of 91.1%, and 99 of 145 . I am hesitant to go to surgery with the 30% cancer chance without more information. I refuse to rush as there are long-term consequences either way. But it is saying that actual surgical results show that 40% "suspicion" turns out to send lots of people to surgery and then about 50% of the surgeries done yield results that show that the nodules were not cancerous at all. It's really upsetting to suddenly be thrust into this with no symptoms, etc. The Annual International Thyroid Cancer Survivors' Conference and Regional Workshops, Download our free Low-Iodine Cookbook (PDF), Rally for Research and Thyroid Cancer Research Grants. The PPV was 50% among GSC suspicious nodules when a variant or fusions was identified, compared with 44% among GSC suspicious nodules when no variant or fusion was identified (p = 0.77 [2]). Here n this 2014 discussion member Olivia-T who was 69 when she posted this and had hurthle cell neoplasm that tripled in size in 10 months,and got a 40% suspicious from the Afirma test,and did post a follow up that did turn out to have thyroid cancer,says here that her oncologist said that her last two patients who had surgery also because of the 40% suspicious for cancer DNA test turned out to have benign tumors. GEC's SE and SP among studies ranged from 78.0 to 100% and 7.7 to 51.7%, respectively. Thus, 54 NIFTP cases were established, all with a suspicious Afirma GEC result. A publication of the American Thyroid Association, Suspicious readings of the Afirma gene-expression classifier include some noninvasive encapsulated follicular variant of papillary thyroid carcinomas. Methods: Mol Genet Genomic Med. Since then, I've had yearly scans (ultrasounds) and two biopsies, both came back negative. Patients usually return home or to work after the biopsy without any ill effects. As said I have a lot of great important articles by many different endocrinologists written at different times for The American Thyroid Association's journal criticizing the Afirma test and how 48% (I'm sure it's much higher!) Epub 2017 Feb 2. Here's what a friend of mine wrote who is a retired neurologist: "They can both be right for different reasons, or from different perspectives. Afirma GEC or GSC a gene-expression classifier that identifies biopsies as "benign" or "suspicious," and mir-THYtype an mRNA-based classifier test. So I thought I was in the clear, and decided to just monitor this nodule for growth, and revisit the surgery idea only if size became an issue. He is very calm and laid back, and prefers to take a more controlled approach to everything, but I'm feeling a more aggressive approach is warranted. Afirma result was suspicious in 69 cases. I am so glad to find this as reading everyone's story helps me feel not so aloneTHANK YOU! The two most common molecular marker tests are the Afirma Gene Expression Classifier and Thyroseq, A publication of the American Thyroid Association, Change In Thyroid Nodule Volume Calculator, Find an Endocrinology Thyroid Specialist, Clinical Thyroidology for the Public (CTFP). False positive rate of Afirma was 56% (32/57). Hello, The remaining 18% were malignant. I could feel food getting lodged in my throat, and felt a pinch like a nerve at times, too. B. and transmitted securely. (Afirma GSC suspicious, suspicious for malignancy, or malignant cytopathology) ,2,4,8 The benign call rate for GSC was 76.2%. Afirma; FNA; cytology; thyroid nodules. She has other small nodules on her other thyroid lobe. http://www.glandsurgery.org/article/view/1002/1193 Biotech Strategy Blog in this post by Pieter Droppert June 28,2012 Also mentions 48% of nodules falsely called "suspicious" for cancer and can cause many people to have unnecessary thyroid surgery when they don't have cancerous thyroid cells! However, researchers found that when the Afirma GSC identified a thyroid nodule with a TSHR mutation as suspicious, the risk of malignancy was 15.3%, a level of risk for which most physicians. The Afirma GEC is a microarray-based molecular test that uses a machine learning-derived classification algorithm to further classify indeterminate thyroid nodules into benign and suspicious categories. However, the results are not conclusive. Background: The Afirma Gene Expression Classifier (GEC) has been used to further characterize cytologically indeterminate (cyto-I) thyroid nodules into either benign or suspicious categories. Cancer-Associated Genes: these are genes that are normally expressed in cells. Like I said I'm doing ok and compared to what I see about the aftermath of having my thyroid removed, I sometimes just want to leave it alone and keep an eye on it instead. Don't get me wrong, it hurts, but I'm able to swallow (soft foods) and talk ok. The .gov means its official. Of the 343 nodules that underwent the GEC test, 178 cases (51.9%) were considered suspicious for cancer. More than one doctor has told me I should just have surgery, at least half the thyroid, maybe the whole thing. Follicular Neoplasm. Thyroid nodule: an abnormal growth of thyroid cells that forms a lump within the thyroid. He said there was no lymph node involvement but there's no way to tell until final path. 6. That not only had the nodule continued to grow (from 2.0 to 3.2cm over the last 2 years), but it is now showing increased central vascularity. The range of confirmed cancer (post surgery) from different studies was as low as 17% to as high as close to 50%. Christmas got in the way, so January 22 is my date. Of the 164 nodules included in the study with the GSC test, suspicious nodules were found in 39 of the 164 nodules (23.7%). This occurs in 15-20% of biopsies and often results in the need for surgery to remove the nodule. How they found it was my complaint of feeling tired all the time. For those of you that had a thyroidectomy, how long did it take for you to realize that the medicine was or was not enough for you? But in my case, it was a risk well worth taking. Until now, Afirma has been available as two tests: Afirma GSC and Afirma Xpression Atlas (XA). suspicious - ~50% risk of cancer. Of course I could have gotten very lucky and caught a cancer in it's early stages, but as well, I do not want to remove a healthy organ . No one was telling me that. I am scheduled to have a TT on March 9th and I wish I felt a little better about my decision. Should I be treating this as a Hurthle Cell Lesion, or should I just relax. Anyone here have a false NEGATIVE Afirma GEC result? It seems like with every ultrasound, some new suspicious characteristic pops up. It's pretty difficult being the patient trying to sort this all out. One > 4cm, but has tested benign by FNA 4 times 2021 Apr;10(2):168-173. doi: 10.1159/000509037. Upenn top thyroid pathologists including Dr.Virginia Lavosi report that follicular neoplasms with oncocytic (hurthle cells)often are misclassified as suspicious by the Afirma test! In such cases, testing of molecular markers related to thyroid cancer may help determine the risk of cancer. Second, this nodule has been stable and has not grown from the first day it was discovered. I'm not sure what the exact terminology is going to be. I wasn't one to resist. I am so new to all this that I don't know what this means. See Somatic Mutation Testing - Solid Tumors guideline for criteria. At the end of the day, it is what it is now that I SWALLOWED (no pun intended) the I-131 pill, hopefully it won't work against me. I regard this as a substantial cost for it's possible contribution to avoiding diagnostic surgery,in part because it also misclassifies lesions as suspicious about half the time. 3. 4. My Endo thinks I should see a thyroid surgeon and my other doctor wants to repeat ultrasounds in 4 months, adopting a wait and see approach. Unauthorized use of these marks is strictly prohibited. The Afirma Genomic Sequencing Classifier (GSC) result was "Suspicious," but the usual orange color (representing ~50% risk of malignancy) of this result is replaced with gray, foreshadowing that . Home Patients Portal Clinical Thyroidology for the Public October 2016 Vol 9 Issue 10 p.11-12, CLINICAL THYROIDOLOGY FOR THE PUBLIC My Enfo bumped up my Synthroid right away to adjust for the surgery. Finally, at the endocrinologist's visit, he told me the results came back as suspicious for papillary cancer on both sides, and that I'd need to have a TT. One such test is the Afirma gene test. Everyone's story and experience seemed to be totally different. Thyroid 2016;26:911-5. Patients with thyroid nodule biopsies with indeterminate cytology results were chosen for additional genetic testing; the Afirma GEC (during the period February 2, 2011July 11, 2017) or the Afirma GSC (during the period July 11, 2017December 19, 2018). They sent me home with 125mcg of Synthroid, calcitrol, and calcium. They were incredibly supportive and also concerned. A 36% Increase in Specificity With Afirma GSC Versus Older Test . On this topic from this forum member bmcm2girls said she too had a false suspicious result from the Afirma test and her nodule was benign when removed. And she's just mostly silent about it. Thyroid Fine Needle Aspiration Biopsy (FNAB): a simple procedure that is done in the doctors office to determine if a thyroid nodule is benign (non-cancerous) or cancer. I tried to avoid it for 10 years I am 52 years old , I have a multinodular goiter with many, many , many nodules,the biggest on the left side 2.2 cm right side 2.6 all TSH test results are good , in fact , my thyroid is fonctioning perfectly well. Silaghi CA, Lozovanu V, Georgescu CE, Georgescu RD, Susman S, Nsui BA, Dobrean A, Silaghi H. Front Endocrinol (Lausanne). Cytopathol. It's barely even hoarse. Once you go down the hole, there are no good statistics to guide you in making rational decisions in an irrational area of medicine - AND as you know, no decisions in medicine in even cut and dried cases are so simple as to have no opposing point of view. Thyroid. What was your experience? See Somatic Mutation Testing - Solid Tumors guideline for criteria. My thyroid nodule (1.5 cm) was discovered by mistake; the technician was only supposed to do an ultrasound on my gallbladder and ovaries, but for some reason did my thyroid as well. He tried to console me but he was also upset. result (eg, benign or suspicious) Public Comment. Current analysis of thyroid biopsy results cannot differentiate between follicular or hurthle cell cancer from noncancerous adenomas. Hopefully soon afterward, I'll learn about whether or not the cells are cancerous and can begin to plan my next steps toward recovery. The doctor uses a very thin needle to withdraw cells from the thyroid nodule. I know how frustrating, scary and expensive this whole process is.I am sorry that you are going through it!! Unable to load your collection due to an error, Unable to load your delegates due to an error. Papillary thyroid cancer is the most common type of thyroid cancer. doi: 10.1002/mgg3.1288. Can you expand on this? It is unclear whether mutations in these genes cause the cancer or are just associated with the cancer cells. On cytologic evaluation 3.0% of the cases were non diagnostic (ND), 9% benign, 62% AUS, and 26% suspicious for neoplasm (SN). Afirma testing is back "Risk of malignancy: Afirma GSC Suspicious ~50%" "Malignancy classifiers: Negative" "MTC and BRAF classifier results were negative and RET/PTC1 and RET/PTC3 were not detected. Just underwent Afirma and Asurgen testing on the suspicious one. Results came back 50% Suspicious for FN(Follicular Neoplasm) with positive HRAS c.18HRAS c.182A>G (Q61R) The moment that I've been so nervous about finally came yesterday. At first it sounded like only the encapsulated variety was going to be included in the reclassification, but more recently it seems that non-encapsulated and non-invasive FVPTC is also going to be included. With these genetic tests, patients and physicians have more information to feel confident about avoiding surgery or pursuing it based on the test results. A test with a better NPV (negative predictive value), would be more usefu than ever in that situation. Now, I will most probably undergo surgery, I requested only the right side be removed and they will have a pathologist look at it while I am under and then decide if they remove the whole thing. Thyroid Nodules: https://www.thyroid.org/thyroid-nodules/. I don't trust this new Afirma thyroid test for very good reasons. Adherence to Active Surveillance and Clinical Outcomes in Patients with Indeterminate Thyroid Nodules Not Referred for Thyroidectomy. Thyroid bloodwork normal. I have since found several more women who had false Afirma test results and had surgery and their nodules were also benign! There was no follow up in 13% of cases and 87% were resected (50% lobectomies and 50% total thyroidectomies). I also recently found *another* article written by an endocrine surgeon Sam Wiseman from the Department of Surgery ,St.Paul's Hospital University Of British Columbia for the site Gland Surgery where he also points out real concerns that half of patients(as I said I know it's more,from all of the people I have found posting on thyroid boards) with benign nodules wrongly classified as "suspicious" by the Afirma test are getting unnecessary thyroid surgery because this Afirma result influenced a lot of endocrinologists and their patients to have the thyroid surgery! 1) Cytologist did not classify this as a Hurthle Cell Lesion Is it a Hurthle Cell Lesion due to predominance of Hurthle Cells?

Philips Respironics Dreamstation Service Required Codes, Betsy Woodruff Face, Vintage Marionette Puppet, Articles A